Luciana Hannibal

The paper identifies a continuous nutrient-derived dietary gradient that links gut microbiome composition, network structure, and host physiology in adults following long-term diets.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

The paper uses metabolic models to show that gut microbiome composition affects L-tyrosine availability in PKU, suggesting microbiome-targeted therapies.

This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.

This study shows that 2-phospho-L-ascorbic acid treatment improves mitochondrial function and reduces cytotoxicity in HO-1 deficient cells.