Author
Howard Hughes Medical InstituteORCID 0009-0007-8919-7629Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Luis A. Williams, Steven J. Ryan, Vaibhav Joshi…·Graham T. Dempsey
The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.
Pin W. Liu, Hongkang Zhang, Christopher A. Werley…·Owen B. McManus
The paper presents an in vitro model of OA pain using SPARC and a high-throughput all-optical electrophysiology system to screen drugs for pain relief.
Dina Simkin, Timothy J. Searl, Brandon N Piyevsky…·Evangelos Kiskinis
This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.
Evangelos Kiskinis, Joel M. Kralj, Peng Zou…·Adam E. Cohen
The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.