Author

Natalie Jäger

German Cancer Research CenterORCID 0000-0001-9385-4635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David T. W. JonesiD· 3 shared Ivo BuchhalteriD· 3 shared Akihiro FujimotoiD· 2 shared Anne-Sophie Sertier· 2 shared Barbara HutteriD· 2 shared Benedikt BrorsiD· 2 shared Christopher PrevitiiD· 2 shared Laurie Tonon· 2 shared

Activity by Year

2015-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersGenomics

David T. W. JonesORCID

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Author profile →

4 papers

Recent·Most cited

The ITCC-P4 PDX platform of pediatric cancers for preclinical testing

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Robert J. Autry, Joshua J. Waterfall, Elnaz Saberi-Ansari, Charles Bobin, Stelly Ballet, Gaëlle Pierron, Justyna A. Wierzbińska, Andreas Schlicker, Martin Sill, Richard Volckmann, Danny A. Zwijnenburg, , Gudrun Schleiermacher

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours

Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, Shuo Yang, David T. Mulder, Jeffrey P. Bruce, Joseph Nathaniel Paulson, Pichai Raman, Yuankun Zhu, Adam Cain Resnick, Poul H. B. Sorensen, Martin Sill, , Trevor J. Pugh

The paper identifies four immune clusters in pediatric nervous system tumors using RNA-seq data and validates them with multiple methods, highlighting the need for personalized immunogenomic profiling.

bioRxiv · Sep 20, 2022 · PreprintGenomics

A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes

Tyler S Alioto, Sophia Derdak, Timothy A Beck, Paul C Boutros, Lawrence Bower, Ivo Buchhalter, Matthew D Eldridge, Nicholas J Harding, Lawrence Edward Heisler, Eivind Hovig, David T W Jones, Andrew G Lynch, Sigve Nakken, Paolo Ribeca, Anne-Sophie Sertier, , Rolf Kab

This study benchmarks somatic mutation calling in cancer genomes, identifying inconsistencies and proposing solutions to improve accuracy.

Nature Communications · Dec 9, 2015Peer-reviewedGenomics

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

Ivo Buchhalter, Barbara Hutter, Tyler S. Alioto, Timothy A. Beck, Paul C. Boutros, Benedikt Brors, Adam P. Butler, Sasithorn Chotewutmontri, Robert E. Denroche, Sophia Derdak, Nicolle Diessl, Lars Feuerbach, Akihiro Fujimoto, Susanne Gröbner, Marta Gut, , on behalf of the ICGC Verification and Validation Working Group

This study compares whole genome sequencing pipelines across five centers using a uniform tumor-normal sample pair, identifying factors affecting output consistency.

bioRxiv · Jun 12, 2015 · PreprintGenomics