Pichai Raman

Administration of barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transport

The paper tests AAV capsid variants in non-human primates to identify those with improved retrograde transport properties.

OpenPBTA: An Open Pediatric Brain Tumor Atlas

OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.

Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours

The paper identifies four immune clusters in pediatric nervous system tumors using RNA-seq data and validates them with multiple methods, highlighting the need for personalized immunogenomic profiling.

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

annoFuse filters and prioritizes oncogenic gene fusions from RNA-Seq data, improving identification of clinically relevant fusions in cancer datasets.

Diagnosing Cornelia de Lange syndrome and related neurodevelopmental disorders using RNA-sequencing

The paper demonstrates that RNA-seq of B lymphoblastoid cell lines can effectively diagnose neurodevelopmental disorders, including Cornelia de Lange syndrome, with high sensitivity.

Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design

This paper genomically characterizes 261 pediatric cancer patient-derived xenograft models to guide rational clinical trial design and drug development.