Poul H. B. Sorensen

HSPD1 promotes neuroblastoma by augmenting MYCN expression

This study shows HSPD1 enhances MYCN expression and tumorigenesis in neuroblastoma by supporting mitochondrial translation and proteostasis.

GALE-dependent glycoproteome remodelling is a determinant of oncogenic RAS transformation

This study identifies GALE as a key regulator of glycoproteome remodelling in RAS-driven cancer, showing its role in sialylation and tumorigenicity.

OVEREXPRESSION OF TUMORPROTECTIVE CLUSTERIN PREVENTS EXHAUSTION OF TRANSGENIC T CELLS

This study shows that overexpressing clusterin (CLU) in T cells reduces exhaustion markers and improves their function against Ewing sarcoma.

Identifying Rare Germline Variants Associated with Metastatic Prostate Cancer Through an Extreme Phenotype Study

This study identifies rare germline variants associated with metastatic prostate cancer using an extreme phenotype cohort and validates their functional impact.

Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans

This study identifies efk-1/eEF2K as a key factor in C. elegans starvation survival by enhancing DNA repair and reducing oxidative stress through a translation-independent mechanism.

IMMUNOTAR - Integrative prioritization of cell surface targets for cancer immunotherapy

IMMUNOTAR prioritizes and identifies immunotherapeutic targets by integrating RNA-sequencing and proteomics data with public databases to evaluate surface proteins across diverse criteria.

Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors

This study develops CAR T cells specific to oncofetal chondroitin sulfate, demonstrating their ability to target and eliminate tumor cells in vitro and improve survival in vivo.

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral Synucleinopathy.

This study uses spatial transcriptomics to analyze aSyn pathology in mice, revealing metabolic and circadian disruptions at different stages of disease progression.

The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation

This study shows eEF2K is critical for the DNA damage response to cisplatin, promoting p53 activation and DNA repair depending on damage severity.

Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours

The paper identifies four immune clusters in pediatric nervous system tumors using RNA-seq data and validates them with multiple methods, highlighting the need for personalized immunogenomic profiling.

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

The paper shows that α-synuclein pathology in Parkinson's disease activates the NRF2 anti-oxidant response, suggesting it could be a therapeutic target.

RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management

RawTools extracts and analyzes data from Thermo Orbitrap raw files to aid in mass spectrometer system management and performance optimization.