Inayathulla Mohammed

The paper presents the cryo-EM structure of a β1-adrenoceptor-AmpC β-lactamase fusion protein in the inactive state, revealing conformational dynamics and potential for GPCR structure elucidation.

This study investigates whether pulsed electron beams reduce radiation damage in cryo-EM and finds no significant difference compared to conventional illumination.

This study reveals the structural basis of CBS as a filamentous morpheein, showing how dynamic quaternary transitions regulate its activity and stability.

The paper introduces a robotic system for cryo-EM grid preparation that improves sample efficiency and reconstruction quality.

The paper determines the cryo-EM structure of alpha-synuclein fibrils with the E83Q mutation, revealing structural changes linked to enhanced aggregation and pathogenicity.

This study shows synthetic alpha-synuclein fibrils can replicate in mice, causing MSA-like pathology and forming glial cytoplasmic inclusions.

This paper applies low-dose cryo-EM and 4D-STEM ptychography to achieve sub-nanometer resolution 3D reconstructions of frozen hydrated proteins.