Author

Pingwu Zhang

Johns Hopkins UniversityORCID 0000-0002-4643-351XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Donald J. ZackiD· 2 shared Casey J. KeuthaniD· 1 shared Cristina ZibettiiD· 1 shared Cynthia A. BerlinickeiD· 1 shared Debasish SinhaiD· 1 shared Derek S. WelsbieiD· 1 shared Hongkai JiiD· 1 shared James T. HandaiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Donald J. ZackORCID

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2 papers

Recent·Most cited

Identification a Compact Promoter using a New Promoter Selection Strategy and Engineering Hybrid Pol II/III Enable Efficient Genome Editing in Human Retinal Ganglion Cells

Pingwu Zhang, Steven H. Zhang, Yen-Yu Chang, Sean Li, Laura Fan, Weifeng Li, Yukan Duan, Jie Cheng, Casey J. Keuthan, Cynthia A. Berlinicke, Derek S. Welsbie, Donald J. Zack

The paper identifies a compact Pol II promoter and hybrid Pol II/III promoters to enable efficient single-AAV delivery of SpCas9 for genome editing in human retinal ganglion cells.

bioRxiv · Jan 28, 2026 · PreprintMolecular Biology

A widespread decrease of chromatin accessibility in age-related macular degeneration

Jie Wang, Cristina Zibetti, Peng Shang, Srinivas R. Sripathi, Pingwu Zhang, Marisol Cano, Thanh V. Hoang, Shuli Xia, Hongkai Ji, Shannath L. Merbs, Donald J. Zack, James T. Handa, Debasish Sinha, Seth Blackshaw, Jiang X. Qian

This study identifies global decreases in chromatin accessibility in AMD patients, linking epigenetic changes to disease progression and suggesting HDAC11 as a potential therapeutic target.

Nature Communications · Apr 4, 2018Peer-reviewedGenomics