Guoguang Xie

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

The paper maps the spatial organization and functional circuits of the insular cortex involved in different pain dimensions using MERFISH and functional analyses.

This study identifies a circuit involving mPFC Foxp2+ neurons that modulates sensory and affective pain in male mice, with therapeutic implications for chronic pain.

The paper identifies a specific NAcSh D1 subtype that regulates feeding and energy homeostasis through molecular and circuit-level mechanisms.