Jody Rosenblatt

This study shows human bronchial epithelial cells clear rhinovirus by extruding infected cells in two waves, maintaining barrier integrity but promoting viral transmission.

The paper shows that starvation-induced cell extrusion selectively removes DNA-damaged cells, improving tissue fitness through a p53-dependent pathway.

This study identifies Piezo1 as a regulator of focal and reticular adhesions, showing its role in EGFR clathrin-mediated endocytosis on stiff substrates.

This study shows that blocking mechanical damage in airway epithelia during asthma reverses airway remodelling and hyperresponsiveness, suggesting asthma may be curable.

The paper uses spatial multiomic profiling to identify distinct fibrotic epithelial niches in IPF, revealing a KRT5low/KRT17 epithelial population and its association with SPP1 macrophages.

This study shows that basal extrusion drives tumor cell invasion and mechanical shedding of E-cadherin in zebrafish epidermis, with KRas mutations increasing invasion rates and p53 mutations enabling survival at distant sites.

This study identifies a mechanism by which endothelial cells extrude apoptotic cells to maintain vascular barrier integrity using a conserved signaling pathway.