Author

Nancy Ernst

University of LübeckORCID 0000-0002-3248-2425Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Anja LuxiD· 3 shared Ann‐Kathrin Schneider· 3 shared Colin Osterloh· 3 shared Frank PeterseniD· 3 shared Gestur VidarssoniD· 3 shared Katja BieberiD· 3 shared Mareile SchlotfeldtiD· 3 shared Ralf Joachim LudwigiD· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Anja LuxORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An unbiased map of FcγR signaling in neutrophils reveals druggable nodes in immune complex-mediated autoimmune disease

Mareile Schlotfeldt, Colin Osterloh, Anika Kasprick, Carla Zünkeler, Mikko Armbrust, Georg Kaiser, Katharina Schulze Dieckhoff, Thorge Mester, Pia Stüssel, Nancy Ernst, Ann‐Kathrin Schneider, Leonie Voss, Adrian Pablo Mansini, Seyed Mohammad Vahabi, Yulu F. Wang, , Katja Bieber

The paper identifies BTK as a therapeutic target in antibody-mediated autoimmune diseases by mapping FcγR signaling in neutrophils using kinase inhibitors and disease models.

bioRxiv · Oct 19, 2026 · PreprintImmunology

CDK7, CDK9, or CDK11 Inhibition Reduces Neutrophil-Driven Inflammation and Tissue Damage in Experimental Autoimmune Models

Mareile Schlotfeldt, Leonie Voss, Adrian Pablo Mansini, Daniel Mehlberg, Sophia Johannisson, Michael Radziewitz, Ann‐Kathrin Schneider, Seyed Mohammad Vahabi, Yulu Wang, Haley Gainer, Jing Li, Colin Osterloh, Nancy Ernst, Remco Visser, Gestur Vidarsson, , Katja Bieber

Cell Communication and Signaling · Sep 30, 2026Peer-reviewedImmunology

Murine CMV Infection Unmasks Macrophage-Driven Inflammatory Cardiomyopathy in Pkp2, but not in Ttn Mutant Mice

Alexandra Cirnu, Tatjana Williams, Mike Noerpel, Julian Kammerer, Svenja Kannt, Mairin Heil, Laura Kimmel, Paula-Anahi Arias-Loza, Manivel Lhoda, Thomas Hennig, DiyaaElDin Ashour, Sarah‐Lena Puhl, Giuseppe Rizzo, Clément Cochain, Tobias Krammer, , Brenda Gerull

This study shows that murine cytomegalovirus infection exacerbates inflammation in Pkp2 mutant mice but not in Ttn mutant mice, highlighting the interaction between genetic predisposition and environmental factors in cardiomyopathy.

bioRxiv · Jan 28, 2026 · PreprintImmunology

ERK5 is required for neutrophil-mediated ROS release and essential in epidermolysis bullosa acquisita

Sören Dräger, Mareile Schlotfeldt, Leonie Caroline Voß, Sophia Johannisson, Michael Radziewitz, Colin Osterloh, Natalie Gross, Mayumi Kamaguchi, Ann‐Kathrin Schneider, Gestur Vidarsson, Remco Visser, Frank Petersen, Xinhua Yu, Andreas Recke, Nancy Ernst, , Katja Bieber

This study shows ERK5 inhibition reduces neutrophil ROS release and ameliorates EBA, suggesting ERK5 as a therapeutic target in ROS-driven autoimmune diseases.

bioRxiv · Nov 12, 2025 · PreprintImmunology