Gustavo M. Silva

This study investigates the redox-dependent activity of the bacterial deubiquitinase ElaD and its impact on K63-linked polyubiquitin accumulation and stress responses in yeast.

The paper shows that K63 ubiquitin chains accumulate in non-cytosolic compartments during oxidative stress and that VCP/p97 and NPLOC4 regulate their localization and removal.

This study shows that Ubp2, a DUB, is redox-regulated during oxidative stress in yeast, controlling K63-ub chains on ribosomes and restoring translation post-stress.

This study quantifies site-specific ribosome ubiquitination under oxidative stress and identifies stress-specific ubiquitin modification patterns.

The paper shows Rad6 mediates ribosome pausing during oxidative stress, affecting translation and stress response pathways.

The paper identifies K63 ubiquitination sites on ribosomes in yeast under oxidative stress using mass spectrometry, revealing their role in post-initiation translation control.