Sören Müller

This paper introduces SHOCOs, a modular system using patient-derived colorectal tumor organoids and fibroblasts to model tumor microenvironments, showing improved immune response and stromal effects on therapy.

The paper designs Müller glia-specific cis-regulatory elements using deep learning and validates their function in vivo.

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

The paper identifies Grem1-expressing fibroblastic reticular cells as a source of FLT3L that supports dendritic cell homeostasis and function in lymph nodes.

Tangram2 maps cell-to-cell communication by integrating spatial transcriptomics with single-cell RNA sequencing to identify gene expression changes driven by neighboring cell types.

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.

The paper introduces ProjecTILs, a method to project scRNA-seq data onto T cell reference atlases to interpret immune responses and perturbations.

The paper defines universal and specialized fibroblast subtypes across tissues and species using single-cell transcriptomics, revealing their transcriptional regulation by microenvironment.