Matthew B. Buechler

The paper investigates the role of Pi16+ fibroblasts in regulating macrophage homeostasis and skin architecture by analyzing the effects of Csf1 deletion in these cells.

This study identifies EphB4 as a critical mediator of pulmonary fibrosis through genetic and pharmacological approaches, showing reduced ECM gene expression and fibrotic pathology.

This study shows Bigh3 is essential for lung fibrosis by demonstrating its role in fibroblast-macrophage interactions and collagen expression.

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.

This paper introduces a method to align single-cell RNA data across species and tissues using adversarial learning, revealing common cell types like macrophages and fibroblasts.

The paper defines universal and specialized fibroblast subtypes across tissues and species using single-cell transcriptomics, revealing their transcriptional regulation by microenvironment.