Author

Alessandra Castiglioni

GenentechORCID 0000-0002-1761-9761Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Cecilia ChiuiD· 2 shared Jianhuan Zhang· 2 shared Kelly M. LoyetiD· 2 shared Matthieu MasureeliD· 2 shared Minh Thai· 2 shared Shannon J. TurleyiD· 2 shared Sören MülleriD· 2 shared Yagai Yang· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Cecilia ChiuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms

Kate Williams, Stephanie Mittman, Natalie S. Firmino, Jasmine W. Larrick, Zhe Zhang, Caroline Whitty, Hsiao‐Yen Ma, Xin Ren, Cecilia Chiu, Yagai Yang, Jianhuan Zhang, Minh Thai, Helena Païdassi, Matthieu Masureel, Kelly M. Loyet, , Alessandra Castiglioni

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

bioRxiv · Jul 9, 2026 · PreprintImmunology

A Co-culture Cell-Based Reporter Assay for Quantitative Measurement of Integrin αvβ8-Mediated Activation of Latent TGF-β1

Jianhuan Zhang, Minh Thai, Matthieu Masureel, Cecilia Chiu, WeiYu Lin, Tulika Tyagi, Alessandra Castiglioni, Dhaya Seshasayee, Kelly M. Loyet

This paper develops a co-culture assay to measure integrin αvβ8-mediated activation of latent TGF-β1, showing it is sensitive and effective for screening antibodies.

bioRxiv · Jul 3, 2026 · PreprintImmunology

Fibroblast TGF-β3 promotes tissue-residency and survival of CD8 T cells in barrier tissues and tumors

Sunny Z. Wu, Ryan S. Lane, Alessandra Castiglioni, Endi K. Santosa, Alberto Guarnieri, Apple Cortez Vollmers, Christian Cox, Yagai Yang, Hannah S. Bender, Tianhe Sun, Justin A. Shyer, Akshay T. Krishnamurty, Sören Müller, Shannon J. Turley

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

bioRxiv · May 22, 2026 · PreprintImmunology