Author

Tomohiro Yamasaki

National Institutes of HealthORCID 0000-0002-9858-9049Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tomohiro Yamasaki1 paper · Kyoto University

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Mioara LarioniD· 3 shared Tyrone DowdyiD· 3 shared Adrian LitaiD· 2 shared Helena MuleyiD· 2 shared Laurence Zhang· 2 shared Meili ZhangiD· 2 shared Aiguo LiiD· 1 shared Christel Herold Mende· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Mioara LarionORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 12, 2026

SCD1 inhibition synergizes with TMZ to improve IDH1 MUT glioma survival of mice via lipotoxic stress

Laurence Zhang, Tomohiro Yamasaki, Viney Kumar…·Mioara Larion

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

DOI 10.64898/2026.06.09.731222

mouseproteomics

Cancer BiologybioRxivPreprintApr 26, 2024

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

Tyrone Dowdy, Helena Muley, Adrian Lita…·Mioara Larion

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

DOI 10.1101/2024.04.26.591321

humanmetabolomics

Cancer BiologybioRxivPreprintApr 26, 2024

DMT1 contributes to MF- 438 - mediated inhibition of glioma cells

Laurence Zhang, Tomohiro Yamasaki, Tyrone Dowdy, Mioara Larion

The paper shows MF-438 inhibits glioma growth through both SCD1-dependent lipid metabolism disruption and SCD1-independent DMT1 suppression.

DOI 10.1101/2024.04.26.591407

humanbulk RNA-seq