Molecular BiologyJournal of Clinical InvestigationPeer-reviewed
Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis
Ratnakar Tiwari, Rajni Sharma, Ganeshkumar Rajendran…·Pinelopi P. Kapitsinou
This study shows that inactivating PHD enzymes in endothelial cells after ischemic kidney injury promotes maladaptive repair through glycolysis and MCT4, which can be reversed by MCT4 inhibitors.