ImmunologyImmunityPeer-reviewed
ICOS limits memory-like properties and function of exhausted PD-1+ CD8 T cells
Étienne Humblin, Isabel Korpas, Nataliya Prokhnevska…·Alice Oliffson Kamphorst
This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.
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