Author

Dane M. Wolf

University of CambridgeORCID 0000-0002-0811-1114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Alva M. CaseyiD· 2 shared Michael P. MurphyiD· 2 shared Patrick Francis ChinneryiD· 2 shared Alex von KriegsheimiD· 1 shared Arthur KaseriD· 1 shared Chak Shun YuiD· 1 shared Christopher A. PowelliD· 1 shared Clare Elizabeth BryantiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Alva M. CaseyORCID

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2 papers

Recent·Most cited

Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycle

Dane M. Wolf, Endri Mjeku, Mayuko Segawa, Alva M. Casey, Néjma Belaadi, Robin Franklin, Michael P. Murphy, Julien Prudent, Nick S Jones, Patrick Francis Chinnery

The paper uses advanced imaging techniques to study mtDNA dynamics in quiescent human cells, revealing rapid replication and degradation rates and spatial organization of mtDNA.

bioRxiv · Jun 3, 2026 · PreprintCell Biology

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

Eloïse Marques, Stephen P. Burr, Alva M. Casey, Richard J Stopforth, Chak Shun Yu, Keira Turner, Dane M. Wolf, Marisa Dilucca, Victoria J. Tyrrell, Robbin Kramer, Yamini M Kanse, Christopher A. Powell, James Bruce Stewart, Michael P. Murphy, Michal A. Minczuk, , Dylan G. Ryan

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

bioRxiv · Jan 5, 2025 · PreprintImmunology