Author

Mary Sophia Mufford

University of Cape TownORCID 0000-0002-8409-9217Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Assay:GWAS summary statistics· 3 Research Focus:GWAS / association mapping· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Dan Joseph SteiniD· 5 shared Christine LöchneriD· 3 shared Paul M. ThompsoniD· 3 shared Shareefa DalvieiD· 3 shared Jonathan IpseriD· 2 shared Kristoffer N. T. MånssoniD· 2 shared Nastassja KoeniD· 2 shared Neda JahanshadiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersGenetic & Genomic Medicine

Dan Joseph SteinORCID

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Author profile →

5 papers

Recent·Most cited

Shared genetic architecture of brain age gap across 30 cohorts worldwide

Vilte Baltramonaityte, Philippe Jawinski, Marlene Staginnus, Mina Shahisavandi, Boglarka Zsofia Kovacs, Isabel K. Schuurmans, Constantinos A. Constantinides, Ahmad R. Hariri, Alexander Teumer, Amanda Rodrigue, Ami Tsuchida, Amirhossein Manzouri, Andriana Karuk, Anna Elisabeth Fürtjes, Annalisa Lella, , Laura K. M. Han

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

medRxiv · Dec 27, 2025 · PreprintGenetic & Genomic Medicine

Specific amygdala and hippocampal subfield volumes in social anxiety disorder and their relation to clinical characteristics; an international mega-analysis

Ziphozihle Ntwatwa, Jule M. Spreckelmeyer, Janna Marie Bas‐Hoogendam, Jack van Honk, Mary Sophia Mufford, Carl‐Johan Boraxbekk, Jean‐Paul Fouché, Andreas Frick, Tomas Furmark, Heide Klumpp, Christine Löchner, K. Luan Phan, Kristoffer N. T. Månsson, Justine Nienke Pannekoek, Jutta Peterburs, , Nynke A. Groenewold

This study identifies specific amygdala and hippocampal subfield volume differences in social anxiety disorder compared to healthy controls, with associations to comorbid conditions.

bioRxiv · Jan 29, 2024 · PreprintNeuroscience

The Genetic Architecture of Amygdala Nuclei

Mary Sophia Mufford, Dennis van der Meer, Tobias Kaufmann, Oleksandr Frei, Raj Ramesar, Paul M. Thompson, Neda Jahanshad, Rajendra A. Morey, Ole A. Andreassen, Dan Joseph Stein, Shareefa Dalvie

This study identifies genetic loci associated with amygdala nuclei volumes using UK Biobank data, finding both unique and shared genetic architectures and immune-related pathways.

Biological Psychiatry · Jun 28, 2023Peer-reviewedGenetic & Genomic Medicine

Polygenic risk associations with developmental and mental health outcomes in childhood and adolescence: A systematic review

L.B. Moyakhe, Shareefa Dalvie, Mary Sophia Mufford, Dan Joseph Stein, Nastassja Koen

This review identifies polygenic risk scores (PRS) for neurodevelopmental and mental health disorders associating with adverse outcomes in childhood and adolescence, suggesting shared genetic factors across these conditions.

medRxiv · Mar 31, 2023 · PreprintGenetic & Genomic Medicine

Concordance Of Genetic Variation That Increases Risk For Tourette Syndrome And That Influences Its Underlying Neurocircuitry

Mary Sophia Mufford, Josh W. Cheung, Neda Jahanshad, Celia van der Merwe, Linda Ding, Nynke A. Groenewold, Nastassja Koen, Emile Rugamika Chimusa, Shareefa Dalvie, Raj Ramesar, James A. Knowles, Christine Löchner, Derrek P. Hibar, Peristera Paschou, Odile A. van den Heuvel, , Dan Joseph Stein

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.

Translational Psychiatry · Mar 22, 2019Peer-reviewedGenomics