Takumi Chinen

The paper identifies AKIP1 as a novel inner scaffold component essential for centriole integrity through functional genomic analysis and imaging.

This study shows that mutating inx-20, a gap junction gene in C. elegans, extends reproductive span without significantly affecting lifespan.

StateMap integrates CRISPR fitness and gene expression data to map cancer pathway states, identifying therapeutic vulnerabilities in the Hippo pathway.

This paper develops a genetically encoded tool to manipulate microtubule bundling in cells and shows that bundling directly stabilizes microtubules and influences cellular processes.

This study identifies three mechanisms that maintain mother-daughter centriole engagement and describe how structural changes enable their disengagement during mitosis.

This study analyzes end-modified long dsDNA donors in CRISPR-mediated endogenous tagging, showing that 5 biotinylation reduces imprecise insertions and enhances HDR efficiency.

This study identifies mitotic vulnerabilities in AML cells induced by therapeutic agents, showing increased cytotoxicity during mitosis compared to S/G2 phase arrest.

This study analyzes DNA double-strand break repair pathways in CRISPR-mediated gene knock-in, finding that multiple repair mechanisms affect precision and efficiency.