Systems BiologyCell Host & MicrobePeer-reviewed
Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan
Author
University of California, San FranciscoORCID 0000-0001-9843-2255Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan
Tyler C. Detomasi, Gilles Degotte, Sijie Huang…·Charles S. Craik
This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.
Irene P. Chen, James E. Longbotham, Sarah McMahon…·Mélanie Ott
The paper shows that BET proteins are antiviral factors against SARS-CoV-2, and the viral E protein neutralizes BET-mediated post-entry antiviral effects.