Tyler C. Detomasi

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

The paper identifies CWR-1 as a chitin polysaccharide monooxygenase involved in allorecognition in Neurospora crassa, showing its PMO domain mediates cell fusion blockage through protein-protein interactions with CWR-2.