Author

Rahul K. Suryawanshi

Gladstone InstitutesORCID 0000-0001-8374-669XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Mélanie OttiD· 5 shared Nevan J. KroganiD· 5 shared Taha Y. TahaiD· 5 shared Amy DialloiD· 3 shared Danielle L. SwaneyiD· 3 shared Mauricio MontañoiD· 3 shared Yusuke MatsuiiD· 3 shared Adam R. RensloiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

Mélanie OttORCID

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Author profile →

5 papers

Recent·Most cited

MicrobiologyScience AdvancesPeer-reviewedSep 18, 2026

Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells

Yusuke Matsui, Rahul K. Suryawanshi, Mauricio Montaño…·Mélanie Ott

This study shows that SARS-CoV-2's ORF8 protein reprograms macrophages to enhance viral infection of lung epithelial cells, contributing to lung pathology in COVID-19.

DOI 10.1126/sciadv.aee5421

humanspatial transcriptomics

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Systems BiologyCell Host & MicrobePeer-reviewedMay 14, 2026

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan

4 citationstop 1%

humanmouse

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ImmunologyeLifePeer-reviewedNov 19, 2025

The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

Rahul K. Suryawanshi, Priyadarshini Jaishankar, G. J. Correy…·James S. Fraser

This study identifies Mac1 as a therapeutic target for SARS-CoV-2 and demonstrates that AVI-4206, a small molecule inhibitor, reduces viral replication and improves survival in an animal model.

15 citationstop 1%

mouseexperimental assay

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BiochemistryScience AdvancesPeer-reviewedApr 23, 2025

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus-MPro inhibitors with potent in vivo efficacy

Tyler C. Detomasi, Gilles Degotte, Sijie Huang…·Charles S. Craik

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

16 citationstop 1%

humanproteomics

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Molecular BiologyCell ReportsPeer-reviewedJun 27, 2022

Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2

Irene P. Chen, James E. Longbotham, Sarah McMahon…·Mélanie Ott

The paper shows that BET proteins are antiviral factors against SARS-CoV-2, and the viral E protein neutralizes BET-mediated post-entry antiviral effects.

28 citations

humanstatistical model

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