Author

Abigail Pearce

University of CambridgeORCID 0000-0001-9845-0541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Claudia M. SiskiD· 2 shared Graham LaddsiD· 2 shared Aaron DexteriD· 1 shared Anjana SajiiD· 1 shared Edward WillsiD· 1 shared Emily J. A. TayloriD· 1 shared Ho Yan YeungiD· 1 shared Kathleen M. CaroniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

Claudia M. SiskORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintSep 15, 2025

Reducing Foetal Bovine Serum Culture Conditions does not affect GPCR Signalling

Abigail Pearce, Michael Collins, Aaron Dexter…·Graham Ladds

This study shows that reducing foetal bovine serum from 10% to 5% in culture conditions does not significantly affect cell growth or GPCR signalling.

DOI 10.1101/2025.09.15.676239

experimental assay

𝕏 PostBluesky

Pharmacology & ToxicologyJournal of Biological ChemistryPeer-reviewedAug 19, 2025

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Increased RAMP3 expression enhances GLP-1 mediated Glucose Stimulated Insulin Secretion in a Manner Dependent on Ca2+ Mobilisation

Abigail Pearce, Poonam Kumari, Claudia M. Sisk…·Graham Ladds

RAMP3 complexes with GLP-1R at the plasma membrane, shifts signalling toward Ca2+ mobilisation, and enhances insulin secretion in INS-1 832/3 cells; Ramp3 loss blunts GLP-1 responses in mice.

8 citations

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