Claudia M. Sisk

This paper designs a pathway-selective P2Y1R inverse agonist that suppresses inflammation without affecting hemostasis, demonstrating its functional selectivity in vitro and in vivo.

This study shows that reducing foetal bovine serum from 10% to 5% in culture conditions does not significantly affect cell growth or GPCR signalling.

RAMP3 complexes with GLP-1R at the plasma membrane, shifts signalling toward Ca2+ mobilisation, and enhances insulin secretion in INS-1 832/3 cells; Ramp3 loss blunts GLP-1 responses in mice.