Nathan Schoettler

The paper uses single-cell multi-omics data to identify asthma risk genes and their cell-type specific functions in lung immune cells.

The paper identifies disease-specific risk variants and shared effector genes in allergic diseases using functional fine-mapping and expression quantitative trait loci.

This study integrates functional genomics and statistical fine-mapping to identify causal variants, regulatory elements, and effector genes for adult-onset and childhood-onset asthma.

The paper examines gene expression in human lung immune cells after stimulation, finding that genes at asthma risk loci show differential expression and that B cells express HLA-DQA2 and HLA-DQB2, suggesting a novel antigen presentation pathway in asthma.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

This study identifies shared and distinct genetic risk factors for childhood and adult onset asthma using GWAS and transcriptome-wide analysis, finding 61 loci with 23 childhood-specific, 1 adult-specific, and 37 shared.