Xiaoyuan Zhong

Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders

The paper identifies context-specific genetic effects in neuronal activation using single-cell multiomics, revealing NPD risk variants and genes active during stimulation.

Single-cell multiomic profiling of lung immune cells identifies novel asthma risk genes and cell-type specific functions

The paper uses single-cell multi-omics data to identify asthma risk genes and their cell-type specific functions in lung immune cells.

Shared loci but distinct variants underlie genetic architecture of allergic diseases

The paper identifies disease-specific risk variants and shared effector genes in allergic diseases using functional fine-mapping and expression quantitative trait loci.

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.

This study integrates functional genomics and statistical fine-mapping to identify causal variants, regulatory elements, and effector genes for adult-onset and childhood-onset asthma.

Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease

The paper constructs a cell-type-resolved chromatin accessibility atlas in the human intestine and identifies regulatory programs and genetic variants associated with Crohn's disease.

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

This study introduces SUPERGNOVA, a framework for estimating local genetic correlations, and identifies 150 trait pairs with significant local genetic correlations, including autism spectrum disorder and cognitive performance.

Estimating genetic nurture with summary statistics of multi-generational genome-wide association studies

This paper estimates direct and indirect genetic effects using summary statistics from multi-generational GWAS, showing distinct patterns for traits like educational attainment and autism spectrum disorder.

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

The paper performs a metabolome-wide association study to identify CSF metabolite-phenotype associations in neurological and psychiatric disorders.

Genetic Variants and Functional Pathways Associated with Resilience to Alzheimer's Disease

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

Fine-tuning Polygenic Risk Scores with GWAS Summary Statistics

This paper introduces PUMAS, a method to fine-tune polygenic risk scores using GWAS summary statistics, improving predictive performance and statistical power in downstream analyses.