Evgenii Lobzaev

Manipulating the 3D organization of the largest synthetic yeast chromosome

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand

The paper constructs a synthetic yeast chromosome XI and demonstrates how non-coding DNA modifications affect cell fitness, enabling on-demand extrachromosomal circular DNA formation.

Designing human Sphingosine-1-phosphate lyases using a temporal Dirichlet variational autoencoder

The paper designs human Sphingosine-1-phosphate lyase variants using a temporal Dirichlet variational autoencoder to improve therapeutic properties for nephrotic syndrome type 14.