Justin Rustenhoven

Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

An inducible genetic tool for tracking and manipulating specific microglial states in development and disease

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.

Recycling old drugs: cardiac glycosides as therapeutics to target barrier inflammation of the vasculature, meninges and choroid plexus

The paper identifies cardiac glycosides as regulators of neuroinflammatory pathways in brain-barrier tissues using in vitro and ex vivo human models.