FABP8/PMP2 is a positive regulator of PNS myelination
Jiayue Hong, Clémence Roué, Simar Arora…·Sophie Belin
This study shows that increasing PMP2 in Schwann cells enhances myelin thickness without affecting ultrastructure or nerve function.
Author
Albany Medical CollegeORCID 0000-0001-9868-1569Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Jiayue Hong, Clémence Roué, Simar Arora…·Sophie Belin
This study shows that increasing PMP2 in Schwann cells enhances myelin thickness without affecting ultrastructure or nerve function.
Jenica Acheta, Amanda S. Mondschein, Marie Collison…·Yannick Poitelon
This study shows that low-intensity ultrasound increases Schwann cell proliferation and NGF expression by activating TAZ, suggesting a role in promoting neurotrophic support.
Ed Zandro M. Taroc, Enrico Amato, Alexis M. Semon…·Paolo Emanuele Forni
The paper investigates the role of Yap and Taz in OEC and Schwann cell development using single-cell RNA sequencing and conditional ablation in mice, finding differential impacts without affecting GnRH-1 migration.
Michael R. Weaver, Dominika Paula Shkoruta, Marta Pellegatta…·M. Laura Feltri
This study identifies striatin-3 as a Rac1 interactor and shows its role in Schwann cell radial sorting and Hippo pathway regulation during peripheral nervous system development.
Emma R. Wilson, Gustavo Della‐Flora Nunes, Shichen Shen…·M. Laura Feltri
This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.
Lara El-Bazzal, Adeline Spiga Ghata, Clothilde Estève…·Nathalie Bernard‐Marissal
This study identifies FGD4/FRABIN's role in regulating NRG1/ErbB2/3 signaling and myelination in CMT4H, showing that restoring this pathway with niacin reduces myelin outfoldings.
Gustavo Della‐Flora Nunes, Emma R. Wilson, Edward L. Hurley…·M. Laura Feltri
This study shows that mTORC1 and JUN are activated in Schwann cells lacking Prohibitin 1, contributing to demyelination through mitochondrial dysfunction.
Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas…·Kristen L. Zuloaga
This study investigates how sex and high fat diet affect metabolic and hypothalamic disturbances in 3xTg-AD mice, finding sex-specific differences in metabolic outcomes and hypothalamic inflammation.
Sophie Belin, Francesca Ornaghi, Ghjuvan’Ghjacumu Shackleford…·Lawrence G. Wrabetz
This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.