Ed Zandro M. Taroc

Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development

The paper analyzes single-cell RNA sequencing data from chick midbrain development to uncover gene regulatory networks and signaling interactions shaping ectodermal patterning.

Human ectodermal organoids reveal the cellular origin of DiGeorge Syndrome

The paper uses human ectodermal organoids to study DiGeorge Syndrome, showing defects in neural crest development and identifying key genes involved.

Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH-1 Migration

The paper investigates the role of Yap and Taz in OEC and Schwann cell development using single-cell RNA sequencing and conditional ablation in mice, finding differential impacts without affecting GnRH-1 migration.

Illuminating the Terminal Nerve: Uncovering the Link between GnRH-1 and Olfactory Development.

This study identifies Prokr2 expression in terminal nerve neurons and links their dysfunction to Kallmann syndrome through single-cell RNA sequencing and genetic tracing in mice.

Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

The paper shows that AP-2ε reprograms vomeronasal sensory neurons and their behaviors by controlling gene expression, bypassing cellular plasticity restrictions.

Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.

This study identifies Notch1 receptor and Dll4 ligand differential expression in neuronal precursors and shows their role in determining the binary dichotomy of vomeronasal neuron types in mice.

Identifying Isl1 genetic lineage in the developing olfactory system and in GnRH-1 neurons

The paper identifies the genetic lineage of Isl1 in developing olfactory system cells and GnRH-1 neurons in mice using genetic and molecular techniques.

Gli3 regulates vomeronasal neurogenesis, olfactory ensheathing cell formation, and GnRH-1 neuronal migration.

This study shows Gli3 is critical for olfactory ensheathing cell development and GnRH-1 neuronal migration, and identifies a GLI3 mutation in a Kallmann syndrome patient.

Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons

This study shows that Smad4 signaling is essential for the development, function, and circuit formation of basal vomeronasal sensory neurons.

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

This study shows that AP-2ε maintains basal vomeronasal sensory neuron identity by preventing apical gene expression and highlights their differentiation plasticity.

Olfactory and vomeronasal innervation of the olfactory bulbs are not essential for GnRH-1 neuronal migration to the brain.

This study shows that proper olfactory bulb development and olfactory/vomeronasal axonal connections are not required for GnRH-1 neuronal migration to the hypothalamus.