Robert K. McGinty

Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.

Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM

This paper introduces a method using Ni-NTA lipid monolayers to improve cryo-EM grid preparation, enabling high-resolution structure determination of proteins and the nucleosome.

An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA

This study identifies an intrinsically disordered region in KDM5A that binds the nucleosome's acidic patch and DNA, enabling catalytic activity through multivalent interactions.

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation

The paper shows that Set8 and L(3)mbt affect gene expression in Drosophila independently of H4K20 methylation, as their mutants have distinct transcriptomes despite similar H4K20me1 reductions.