Author

Yuanchao Xie

Chinese Academy of SciencesORCID 0000-0001-9875-887XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Research Focus:sequence-to-function modeling· 1 Organism:virus· 1

Frequent Co-Authors

Hualiang JiangiD· 2 shared Jingshan SheniD· 2 shared Chunhui WuiD· 1 shared Chunyou MaoiD· 1 shared Cui CheniD· 1 shared Dandan SheniD· 1 shared Feipu YangiD· 1 shared Feisheng ZhongiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioinformatics

Hualiang JiangORCID

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2 papers

Recent·Most cited

BioinformaticsEuropean Journal of Medicinal ChemistryPeer-reviewedJul 11, 2020

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

Xiaoqin Tan, Xiangrui Jiang, He Yang…·Hualiang Jiang

This paper develops a deep learning system to design multitarget antipsychotic drugs, generating novel compounds with activity against multiple receptors and demonstrating efficacy in animal models.

45 citations

deep learningdrug response / drug discovery

Molecular BiologySciencePeer-reviewedMay 1, 2020

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan…·H. Eric Xu

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

1,219 citationstop 1%

virusexperimental assay