PathologyScience Translational MedicinePeer-reviewed
Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis
Hongxue Shi, Xiaobo Wang, D. Christopher Sloas…·Ira A. Tabas
This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.