Chyuan‐Sheng Lin

A mutation-agnostic and allele-specific ASO strategy demonstrates potent functional rescue and retinal preservation in RHO-linked retinitis pigmentosa

This paper develops an allele-specific ASO strategy, SNARE, that selectively suppresses mutant RHO transcripts in RHO-linked retinitis pigmentosa, demonstrating functional rescue and retinal preservation in both in vitro and in vivo models.

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes

The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.

Phospholipase Cgamma regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism

This study shows that PLCgamma competes with PI3K in phosphoinositide metabolism to regulate lacrimal gland branching.

Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung

The paper identifies the Foxa2 lineage's role in lung development and demonstrates that conditional complementation of this lineage can generate a whole lung in mice.

Release of stem cells from quiescence reveals multiple gliogenic domains in the adult brain

The paper identifies multiple gliogenic domains in the adult V-SVZ by studying PDGFRβ-expressing NSCs and their release from quiescence.