Author

Praveen Sethupathy

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Genomics· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andreas StephanouiD· 2 shared Matt KankeiD· 2 shared Adrian J. McNairniD· 1 shared Alaa R. FarghliiD· 1 shared Alessandra Bonito-OlivaiD· 1 shared Alice YoungiD· 1 shared Andrea Araceli Terceros· 1 shared Andrew D Miller· 1 shared

Activity by Year

2013-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

Andreas StephanouORCID

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Author profile →

5 papers

Recent·Most cited

Spatial analysis of canine glioma reveals heterogeneous intratumoral niches characterized by distinct patterns of cell plasticity and immunosuppression

Sophie R. Nelissen, Andreas Stephanou, Eric N. Glass, James Hammond, Gena Silver, Praveen Sethupathy, Iwijn De Vlaminck, Andrew D Miller, Elena A. Demeter

The paper analyzes canine glioma samples to reveal heterogeneous intratumoral niches with distinct cell plasticity and immunosuppression patterns, highlighting similarities to human gliomas.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

Genetic mapping identifies Homer1 as a developmental modifier of attention

Zachary Gershon, Alessandra Bonito-Oliva, Matt Kanke, Andrea Araceli Terceros, Genelle Rankin, John J. Fak, Yujin Harada, Andrew F. Iannone, Millennium Gebremedhin, Brian A. Fabella, Natalia V. De Marco García, Praveen Sethupathy, Priyamvada Rajasethupathy

This study identifies Homer1 as a gene that modulates attention by altering prefrontal cortex inhibitory tone and signal-to-noise ratio in mice.

Nature Neuroscience · Dec 22, 2025Peer-reviewedNeuroscience

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini, Mareike Schell, Kiran J. Biddinger, Matt Kanke, George Pengo, Ivana Semova, Tiffany Fougeray, Marcia C. Haigis, Krishna G. Aragam, Wouter H. Lamers, Linus T.-Y. Tsai, Praveen Sethupathy, Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

Molecular Metabolism · Jul 16, 2025Peer-reviewedPhysiology

Single-cell multi-omic analysis of fibrolamellar carcinoma reveals rewired cell-to-cell communication patterns and unique vulnerabilities

Alaa R. Farghli, Marina Chan, Marc Samuel Sherman, Lindsay K. Dickerson, Bo Shui, Manabu Nukaya, Andreas Stephanou, Rosanna K. Ma, Brian J. Pepe-Mooney, Colton J. Smith, Donald Long, Paul R. Munn, Adrian J. McNairn, Jennifer K. Grenier, Michael Karski, , Praveen Sethupathy

This study uses single-nucleus multi-omics to analyze fibrolamellar carcinoma, revealing rewired cell communication and potential therapeutic targets.

bioRxiv · Dec 11, 2024 · PreprintCancer Biology

Massively differential bias between two widely used Illumina library preparation methods for small RNA sequencing

Jeanette Baran-Gale, Michael R Erdos, Christina Sison, Alice Young, Emily E Fannin, Peter S Chines, Praveen Sethupathy

This study compares two small RNA library preparation methods and finds significant differential bias in miRNA detection between them.

bioRxiv · Dec 19, 2013Genomics