Alicia Izquierdo

Sex differences in task engagement and lapse rate during reward learning

This study investigates sex differences in reward learning by analyzing task engagement and lapse rates in rats during stimulus- and action-based learning and their reversals.

A progressive ratio task with costly resets reveals adaptive effort-delay tradeoffs

This paper introduces a modified Progressive Ratio task with reset options to study adaptive effort-delay tradeoffs in rats, finding they exhibit systematic biases in their decision-making strategies.

Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex

The paper investigates how uncertainty modulates neural coding of choice and outcome in orbitofrontal (OFC) and secondary motor cortex (M2) during reward learning, finding differential roles in encoding under varying uncertainty levels.

A common stay-on-goal mechanism in anterior cingulate cortex for information and effort choices

This study shows the anterior cingulate cortex supports persistence toward certain and valuable rewards in both information and effort choices.

A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information

The paper shows that anterior cingulate cortex inhibition disrupts information-based choice preference in female rats, suggesting a sex-dependent role for ACC in decision-making involving information.

Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty

This study investigates the distinct roles of vlOFC and BLA in stimulus- and action-based reversal learning under uncertainty using chemogenetic inhibition in rats.

A novel hypothalamic-midbrain circuit for model-based learning

This paper identifies a novel hypothalamic-midbrain circuit that supports model-based learning and shows its alteration in methamphetamine use.

Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

This study investigates how mice and monkeys adjust to different types of uncertainty in reward environments using choice data and reinforcement learning models.

DeCalciOn: A hardware system for real-time decoding of in-vivo calcium imaging data

DeCalciOn is a hardware system for real-time decoding of in vivo calcium imaging data, enabling closed-loop feedback experiments with millisecond latency.

Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning

This study investigates how theta oscillations in ACC and OFC affect accuracy and speed in reward learning, finding ACC inhibition impairs reversal learning while OFC theta remains unaffected.

The Orbitofrontal Cortex in Temporal Cognition

This review reevaluates theories of orbitofrontal cortex function by incorporating temporal information into value estimation and decision making.

Chemogenetic modulation and single-photon calcium imaging in anterior cingulate cortex reveal a mechanism for effort-based decisions

This study uses chemogenetics and calcium imaging in rats to show that anterior cingulate cortex (ACC) discriminates between reward options, influencing effort-based decisions.

Dissociable roles for Anterior Cingulate Cortex and Basolateral Amygdala in Decision Confidence and Learning under Uncertainty

This study investigates the roles of the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) in decision confidence and learning under uncertainty using a rat behavioral task.