Jeremiah Y. Cohen

Topographic structure and function of locus coeruleus norepinephrine neurons

The paper identifies topographic organization in locus coeruleus norepinephrine neurons, linking their morphology, gene expression, and activity to specific brain regions and learning-related behaviors.

Cell-type-specific sustained value representations in the claustrum

The paper identifies two distinct neuron populations in the claustrum that encode reward rate and influence decision-making through graded activity patterns.

Serotonin predictively encodes value

This paper proposes a theory that serotonin neurons encode predictive value signals, explaining various serotonergic responses better than existing theories.

Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

This study investigates how mice and monkeys adjust to different types of uncertainty in reward environments using choice data and reinforcement learning models.

Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Mouse locus coeruleus norepinephrine neurons split into wide-spike and thin-spike subtypes that oppositely encode positive reward prediction errors and reward omission to drive reinforcement learning.

Norepinephrine Potentiates and Serotonin Depresses Visual Cortical Responses by Transforming Eligibility Traces

Serotonin neurons modulate learning rate through uncertainty

This study shows that serotonin neurons in mice track uncertainty during learning tasks and modulate learning rates accordingly.

Novel entropy-based metrics for predicting choice behavior based on local response to reward

The paper introduces entropy-based metrics to predict choice behavior in mice and monkeys, explaining 50% and 41% of matching variance, and develops a more accurate model based on these metrics.

Locus coeruleus spiking differently correlates with somatosensory cortex activity and pupil diameter

The paper examines the temporal relationships between locus coeruleus spiking, somatosensory cortex activity, and pupil diameter in mice during a tactile detection task, finding that pupil diameter is not a reliable stationary index of LC activity.

Neuron-type specificity of dorsal raphe projections to ventral tegmental area

The paper investigates DR to VTA projections in mice using single-cell RNA sequencing, showing anatomical and functional specificity of serotonergic and glutamatergic neurons.

A history-derived reward prediction error signal in ventral pallidum

This study identifies RPE signals in the ventral pallidum that predict task engagement and influence reward-seeking behavior in rats.

Punishment history biases corticothalamic responses to motivationally-significant stimuli

The paper shows that punishment history affects corticothalamic responses to relevant stimuli, leading to biased behavior in mice.

A Clock-Driven Neural Network Critical for Arousal

This study identifies a conserved clock-regulated neural network in mice and Drosophila that controls arousal and sleep, showing that mWake+ cells are critical for circadian-dependent neural excitability.