Helen Wheadon

LIMK Inhibition and Metformin Block Mitochondrial Transfer Overcoming Macrophage Driven Therapy Resistance in Acute Myeloid Leukaemia

This study identifies mitochondrial transfer from M2-like macrophages to AML cells as a mechanism of chemoresistance, showing that LIMK inhibition and metformin block this transfer and restore chemosensitivity.

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells

This study shows DRx-098D, a peptide disrupting MDM2 dimerisation, effectively inhibits cancer cell growth in TP53 wild-type and mutant cell lines, outperforming Idasanutlin in TP53 null cells.

Using topic modeling to detect cellular crosstalk in scRNA-seq

The paper introduces a topic modeling method using LDA to detect gene expression changes in interacting cells from scRNA-seq data, applied to synthetic and real datasets.