Author

Gabriel L. A. Silva

University of GlasgowORCID 0009-0001-3114-2314Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Richard McCullochiD· 4 shared Craig T. LapsleyiD· 3 shared Jeziel D. DamascenoiD· 3 shared Jennifer Ann BlackiD· 2 shared Luíz Ricardo Orsini TosiiD· 2 shared Catarina A Marques· 1 shared Catarina A. MarquesiD· 1 shared Dario BeraldiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

Richard McCullochORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 30, 2026

Single-cell transcriptomics reveals life cycle and cell cycle gene expression dynamics during in vitro growth of two Leishmania species

Catarina A Marques, Ross F Laidlaw, Felix Warren…·Emma M. Briggs

This study uses single-cell transcriptomics to analyze life cycle and cell cycle gene expression dynamics in two Leishmania species during in vitro growth, revealing developmental endpoints and cell cycle-related gene expression patterns.

DOI 10.64898/2026.09.29.755301

mousescRNA-seq

𝕏 PostBluesky

Molecular BiologyPLoS GeneticsPeer-reviewedNov 24, 2025

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.

Gabriel L. A. Silva, Jeziel D. Damasceno, Jennifer Ann Black…·Luíz Ricardo Orsini Tosi

This study shows that ATR modulates DNA replication timing in Leishmania major, promoting genome stability by preventing replication stress-induced chromosome instability.

3 citations

experimental assay

𝕏 PostBluesky

MicrobiologyCell ReportsPeer-reviewedAug 1, 2025

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Jeziel D. Damasceno, Gabriel L. A. Silva, Catarina A. Marques…·Richard McCulloch

9 citationstop 2%

Drosophilalong-read sequencing

𝕏 PostBluesky

Molecular BiologybioRxivPreprintNov 4, 2024

Genome-wide mapping of RPA1 and RAD9 reveals the management of polycistronic transcription, replication initiation, and responses to replication stress in Leishmania

Jennifer Ann Black, Stela Virgílio, Matheus Silva e Bastos…·Luíz Ricardo Orsini Tosi

This study maps RPA1 and RAD9 in Leishmania to understand replication stress response, showing stress hotspots correlate with replication initiation and transcription termination.

1 citation

ChIP-seqstatistical model

𝕏 PostBluesky