Author

Annabelle Biscans

University of Massachusetts Chan Medical SchoolORCID 0000-0001-9953-9265Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:plant (other)· 1 Organism:rat· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 1 shared Claudio PunzoiD· 1 shared Cristiana BarradasiD· 1 shared Delaney Giguere· 1 shared Dimas EcheverriaiD· 1 shared Emma InganäsiD· 1 shared Hernando Yesid EstupiñaniD· 1 shared Hoang‐Ngoan LeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Anastasia KhvorovaORCID

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2 papers

Recent·Most cited

Lipid-ASO therapeutics exhibit differential tissue targeted delivery upon systemic or local CNS administration

Samantha Roudi, Hernando Yesid Estupiñan, Osama Saher, Cristiana Barradas, Emma Inganäs, Hoang‐Ngoan Le, Nicolai Sebastian Frengen, Radosław Grochowski, Svetlana Pavlova, Robert Månsson, Joel Z. Nordin, Annabelle Biscans, Pär Matsson, Rula Zain, Rickard Sandberg, , Samir EL Andaloussi

This study compares lipid-conjugated ASO delivery in mice, showing differential tissue and CNS targeting based on lipid type and administration route.

bioRxiv · Sep 2, 2026 · PreprintPharmacology & Toxicology

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors

Shun-Yun Cheng, Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh, Matthew R. Hassler, Samson M. Jolly, Delaney Giguere, Joris Cipi, Anastasia Khvorova, Claudio Punzo

This study evaluates tetravalent siRNA configurations for photoreceptor gene silencing, finding that tetravalent siRNA provides robust, long-lasting efficacy with a good safety profile in rodent and swine models.

Molecular Therapy — Nucleic Acids · Dec 5, 2023Peer-reviewedNeuroscience