Samantha Roudi

This study shows that chemical modifications to siRNA and linkers in AOCs can improve potency and tissue targeting while allowing higher payload loading.

This study compares lipid-conjugated ASO delivery in mice, showing differential tissue and CNS targeting based on lipid type and administration route.

This paper demonstrates efficient genome editing in non-human primate brains using engineered extracellular vesicles, achieving therapeutic potential for neurological disorders.

This study develops an engineered extracellular vesicle platform that improves shRNA loading and delivery efficiency, achieving robust gene silencing in multiple cell types and the mouse brain.

This study develops a click chemistry-based strategy for siRNA conjugation to enhance extrahepatic RNAi, finding that bis-fatty-acid conjugates improve activity in heart and muscle while showing modality-specific limitations.

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

This paper develops hPep peptide-based nanoparticles for systemic mRNA delivery, showing effective tissue distribution and protein expression in mice and non-human primates.

This paper develops hPep-based nanoparticles for efficient delivery of gene editors across multiple cell types, achieving high editing efficiency in human cells.

The paper identifies 24 novel scaffold proteins with conserved EV-sorting abilities, outperforming CD63 in cargo loading and demonstrating improved EV engineering potential.