Hernando Yesid Estupiñan

Lipid-ASO therapeutics exhibit differential tissue targeted delivery upon systemic or local CNS administration

This study compares lipid-conjugated ASO delivery in mice, showing differential tissue and CNS targeting based on lipid type and administration route.

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles

This paper demonstrates efficient genome editing in non-human primate brains using engineered extracellular vesicles, achieving therapeutic potential for neurological disorders.

Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types

This paper develops hPep-based nanoparticles for efficient delivery of gene editors across multiple cell types, achieving high editing efficiency in human cells.