Author

Gary Struhl

Mortimer B. Zuckerman Mind Brain Behavior InstituteORCID 0000-0002-0018-604XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Paul D. LangridgeiD· 2 shared Alejandro Garcia Diaz· 1 shared Amber Ajamu-Johnson· 1 shared Breana WaltoniD· 1 shared Frederick C. BakeriD· 1 shared Iva GreenwaldiD· 1 shared Jacob Harman· 1 shared Jessica Yu Chan· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Paul D. LangridgeORCID

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3 papers

Recent·Most cited

An in vivo screen for proteolytic switches that can mediate Notch activation

Frederick C. Baker, Jacob Harman, Trevor Jordan, Breana Walton, Amber Ajamu-Johnson, Rama F. Alashqar, Simran Bhikot, Gary Struhl, Paul D. Langridge

The paper identifies proteolytic switches that mediate Notch activation in response to force using an in vivo screen in Drosophila.

Science Signaling · Jun 10, 2025Peer-reviewedCell Biology

Context-dependent transcriptional regulation by Drosophila Polycomb Response Elements

Rory T. Coleman, Gary Struhl

This study investigates how PREs regulate gene expression in Drosophila, showing they influence gene expression quantitatively and can act at long range, but their effects depend on context and regulatory interactions.

bioRxiv · May 11, 2022 · PreprintDevelopmental Biology

The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch

Paul D. Langridge, Alejandro Garcia Diaz, Jessica Yu Chan, Iva Greenwald, Gary Struhl

This study shows that C. elegans Notch proteins LIN-12 and GLP-1 have lower force thresholds for activation compared to Drosophila Notch, and a Leucine plug in vertebrate Notch proteins increases force requirements for activation.

Current Biology · Mar 28, 2022Peer-reviewedDevelopmental Biology