Author

Paul D. Langridge

Augusta UniversityORCID 0000-0002-9879-3939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Assay:proteomics· 1

Frequent Co-Authors

Gary StruhliD· 2 shared Alejandro Garcia Diaz· 1 shared Amber Ajamu-Johnson· 1 shared Breana WaltoniD· 1 shared Frederick C. BakeriD· 1 shared Iva GreenwaldiD· 1 shared Jacob Harman· 1 shared Jessica Yu Chan· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Gary StruhlORCID

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2 papers

Recent·Most cited

An in vivo screen for proteolytic switches that can mediate Notch activation

Frederick C. Baker, Jacob Harman, Trevor Jordan, Breana Walton, Amber Ajamu-Johnson, Rama F. Alashqar, Simran Bhikot, Gary Struhl, Paul D. Langridge

The paper identifies proteolytic switches that mediate Notch activation in response to force using an in vivo screen in Drosophila.

Science Signaling · Jun 10, 2025Peer-reviewedCell Biology

The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch

Paul D. Langridge, Alejandro Garcia Diaz, Jessica Yu Chan, Iva Greenwald, Gary Struhl

This study shows that C. elegans Notch proteins LIN-12 and GLP-1 have lower force thresholds for activation compared to Drosophila Notch, and a Leucine plug in vertebrate Notch proteins increases force requirements for activation.

Current Biology · Mar 28, 2022Peer-reviewedDevelopmental Biology