R. Weber

Neural graft elimination via dual safety switch compromises therapeutic recovery after stroke

This study shows that using a dual safety switch to eliminate neural grafts after stroke impairs functional recovery despite effective cell ablation.

Targeting integrin αvβ3 by chimeric antigen receptor neural stem cell (CAR-NSC) therapy for stroke

This paper develops CAR-NSC therapy targeting integrin αvβ3 to improve spatial distribution and tissue engagement of transplanted cells in stroke models.

Hypoxia preconditioned neural xenografts promote repair of brain tissue after stroke

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

APOE genotype-dependent differences in human astrocytic energy metabolism

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

A molecular brain atlas reveals cellular shifts during the repair phase of stroke

This study creates a single-cell transcriptomic atlas of the mouse brain after stroke, revealing cell-specific molecular changes and shared features with human stroke lesions.

Delayed transplantation of neural stem cells improves initial graft survival following stroke

This study shows that delayed transplantation of neural progenitor cells after stroke improves graft survival and proliferation in mice.

Spinal cord perfusion impairments in the M83 mouse model of Parkinson's disease

The paper uses multimodal imaging to assess spinal cord oxygenation and vascular changes in a PD mouse model, finding reduced oxygen saturation but no vascular impairment or atrophy.

Visualization and estimation of stroke infarct volumes in rodents

The paper introduces a semi-automated toolkit to estimate stroke infarct volumes in rodents using MRI and histological sections, showing high correlation between the two methods.

Deep learning based behavioral profiling of rodent stroke recovery

This paper develops a deep learning-based method for analyzing rodent stroke recovery using 3D gait tracking and benchmarking against conventional tests.

Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications

This paper develops xeno-free iPSC-derived NPCs compatible with GMP for clinical use, showing long-term survival and differentiation into neurons in vivo.

Molecular and anatomical roadmap of stroke pathology in immunodeficient mice

This study evaluates the impact of immunosuppression on stroke pathology in different mouse models, finding distinct anatomical and molecular changes that affect recovery and inflammation.