Frank L. Heppner

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues

The paper introduces Cryo-mtscATAC-seq to genotype mitochondrial DNA and trace clones in frozen human tissues, revealing clonal patterns in various diseases.

RNA promotes synapsin phase separation providing a platform for local translation

The paper shows RNA promotes synapsin phase separation, forming condensates that organize synaptic vesicles and enhance local translation.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and aging

The paper compares ESC-derived, neonatal, and adult astrocytes to identify functional and transcriptomic differences across age and culture conditions.

Preparation of large-scale digitization samples for automated electron microscopy of tissue and cell ultrastructure

The paper describes a methodology for preparing large-scale digitization samples to enable automated electron microscopy, improving throughput and reducing bias in ultrastructural analysis.

The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer's disease-like pathology by perturbing oligodendrocyte survival and neuronal homeostasis

This study identifies IL-12 as the main driver of neuroinflammation in Alzheimer's disease by affecting oligodendrocyte survival and neuronal homeostasis in a mouse model.

The autophagy activator Spermidine ameliorates Alzheimer's disease pathology and neuroinflammation in mice

This study shows that Spermidine, an autophagy activator, reduces neuroinflammation and Aβ levels in AD-like mice by enhancing autophagy in microglia and astrocytes.

Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

The paper investigates SARS-CoV-2 entry into the CNS via the olfactory mucosa in COVID-19 patients and demonstrates neurotropism and cerebral thromboembolism.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.