Author

Guillaume G. Noell

Wellcome Sanger InstituteORCID 0000-0002-0069-4933Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 2 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1

Frequent Co-Authors

Vivek IyeriD· 3 shared Adam S. ButterworthiD· 1 shared Alex TokolyiiD· 1 shared Artika P. NathiD· 1 shared Ben W. Farr· 1 shared Benjamin B. SuniD· 1 shared Biljana BrezinaiD· 1 shared Bradley T. HarrisiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetic & Genomic Medicine

Vivek IyerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

Monika Krzak, Tobi Alegbe, D. Leland Taylor, Gareth‐Rhys Jones, Mennatallah Ghouraba, Michelle Strickland, Bradley T. Harris, Reem Satti, Kenneth Arestang, Lucia Ramirez-Navarro, Nilanga Nishad, Kimberly Ai Xian Cheam, Marcus Tutert, Matiss Ozols, Guillaume G. Noell, , Carl A. Anderson

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

Nature Genetics · Jun 15, 2026Peer-reviewedGenetic & Genomic Medicine

Genetic determinants of blood gene expression and splicing and their contribution to molecular phenotypes and health outcomes

Alex Tokolyi, Elodie Persyn, Artika P. Nath, Katie L. Burnham, Jonathan Marten, Thomas Vanderstichele, Manuel Tardáguila, David Stacey, Ben W. Farr, Vivek Iyer, Xilin Jiang, Samuel A. Lambert, Guillaume G. Noell, Michael Andrew Quail, Diana Rajan, , Dirk S. Paul

This study identifies genetic determinants of blood gene expression and splicing, linking them to molecular phenotypes and health outcomes through QTL analysis and colocalization.

Nature Genetics · Mar 1, 2025Peer-reviewedGenetic & Genomic Medicine

Minimized double guide RNA libraries enable scale-limited CRISPR/Cas9 screens

Elin Madli Peets, Luca Crepaldi, Yan Zhou, Felicity R. Allen, Rasa Elmentaite, Guillaume G. Noell, Gemma Turner, Vivek Iyer, Leopold Parts

This paper introduces a minimized double guide RNA library for CRISPR/Cas9 screens, reducing scale by fivefold while maintaining performance.

bioRxiv · Nov 29, 2019 · PreprintGenetics