Harry Pantazopoulos

Polysome Profiling Method for Low-Input Human Postmortem Brain

This paper develops a low-input polysome profiling protocol for human postmortem brain tissue and adapts it for neuronal cell lines and mouse brain.

Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use

This study identifies altered molecular pathways in the hippocampus of rhesus monkeys with chronic alcohol use, highlighting mitochondrial and synaptic changes and potential therapeutic targets.

Cross-Species Evidence for Hippocampal CACNA1C as a Therapeutic Target for Alcohol Use Disorder

The paper identifies CACNA1C as a therapeutic target for alcohol use disorder by showing increased expression in AUD and reduced ethanol-induced CPP with Nifedipine.

Sleep Deprivation Alters Hippocampal Dendritic Spines in a Contextual Fear Memory Engram

The paper investigates how sleep deprivation affects dendritic spine density in neurons encoding contextual fear memories, finding reduced spine density in sleep-deprived mice.

Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex

This study shows psilocybin reduces reward-seeking behavior and increases activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex in rats.

Developmental time course of social touch, parvalbumin interneurons, perineuronal nets and Mef2c expression reveals a sensitive period of somatosensory cortex development in prairie voles

This study maps the developmental timeline of parvalbumin interneurons and related markers in prairie voles, identifying a sensitive period for somatosensory cortex maturation linked to social touch.

Spermidine alleviates depression via control of the stress response

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

Molecular Neurobiology of Loss

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.