Sinead Marie O'Donovan

This study identifies altered molecular pathways in the hippocampus of rhesus monkeys with chronic alcohol use, highlighting mitochondrial and synaptic changes and potential therapeutic targets.

The paper identifies CACNA1C as a therapeutic target for alcohol use disorder by showing increased expression in AUD and reduced ethanol-induced CPP with Nifedipine.

This study identifies elevated mRNA expression of AKT isotypes in schizophrenia neurons, suggesting a potential decoupling of transcript and protein levels, with sex-specific differences and involvement of related signaling components.

This study analyzes the proteomic changes in schizophrenia using postmortem brain samples and shows how antipsychotic drugs modulate these changes across multiple biological levels.

The paper identifies CS6 clusters as extracellular matrix microenvironments that support coordinated multi-dendrite synaptic plasticity in response to sensory stimuli.

This study examines the relationship between astrocyte subtypes, neurological and psychiatric diseases, and psychotropic medications using gene enrichment analysis and qPCR, finding that astrocytes are not a primary target of these medications.

Kaleidoscope is a web application that provides access to omics databases and tools for in silico hypothesis exploration, demonstrating its use with DISC1 gene analysis across multiple datasets.

The paper identifies PPAR agonists as potential treatments for schizophrenia by analyzing bioenergetic changes in the DLPFC using bioinformatics and experimental validation.